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Nascent Polypeptide-Associated Complex Involved in the Development and Pathogenesis of Fusarium graminearum Article

Xuli Wang, Xin Xie, Jin Liu, Guo-Liang Wang, Dewen Qiu

Engineering 2020, Volume 6, Issue 5,   Pages 546-552 doi: 10.1016/j.eng.2019.07.025

Abstract: In this study, we characterized the function of the nascent polypeptide-associated complex (NAC) in <

Keywords： Fusarium head blight     Nascent polypeptide-associated complex     Gene knockout     Pathogenicity     Subcellular    

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Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 323-331 doi: 10.1007/s11684-008-0062-6

Abstract: Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been

Keywords： Contraction stimulation     phosphatase-proline     molecular structure     discovered     hypertension    

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Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 459-466 doi: 10.1007/s11684-021-0841-x

Abstract: Whether Fanconi anemia (FA) heterozygotes are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer prevention and family consulting. We retrospectively analyzed rare possibly significant variations (PSVs) in the five most obligated FA genes, BRCA2, FANCA, FANCC, FANCD2, and FANCG, in 788 patients with aplastic anemia (AA) and hematologic malignancy. Sixty-eight variants were identified in 66 patients (8.38%). FANCA was the most frequently mutated gene (n = 29), followed by BRCA2 (n = 20). Compared with that of the ExAC East Asian dataset, the overall frequency of rare PSVs was higher in our cohort (P = 0.016). BRCA2 PSVs showed higher frequency in acute lymphocytic leukemia (P = 0.038), and FANCA PSVs were significantly enriched in AA and AML subgroups (P = 0.020; P = 0.008). FA-PSV-positive MDS/AML patients had a higher tumor mutation burden, higher rate of cytogenetic abnormalities, less epigenetic regulation, and fewer spliceosome gene mutations than those of FA-PSV-negative MDS/AML patients (P = 0.024, P = 0.029, P = 0.024, and P = 0.013). The overall PSV enrichment in our cohort suggests that heterozygous mutations of FA genes contribute to hematopoietic failure and leukemogenesis.

Keywords： Fanconi anemia     aplastic anemia     hematologic malignancy     germline predisposition    

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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposedParticipants without NAFLD but diagnosed according to MAFLD definition were associated with higher riskIn conclusion, MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1361-7

Abstract:

• Bacteria could easily and quickly attached onto TEP to form protobiofilms.

Keywords： Transparent exopolymer particles (TEPs)     TEP-protobiofilm     Bacteria attachment     Biofouling of membrane    

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Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 521-528 doi: 10.1007/s11705-017-1612-8

Abstract: In this study, we developed the cationic, -helical polypeptide that can effectively deliver DNA intoThis study therefore widens the utilities of helical polypeptide as a unique category of gene delivery

Keywords： α-helical polypeptide     plant gene delivery     protoplast     intact leaves     transfection    

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Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery

Yutao Liu, Yaxia Di, Shuai Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 239-246 doi: 10.1007/s11684-017-0509-8

Abstract: We aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients undergoing SHNC

Keywords： ventilator-associated pneumonia (VAP)     pneumonia     risk factors     surgery for head and neck cancer (SHNC)    

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The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid

Yang Wang, Huifang Zhou, Xianqun Fan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 359-364 doi: 10.1007/s11684-017-0528-5

Abstract:

Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder.

Keywords： thyroid-associated orbitopathy     dysthyroid optic neuropathy     orbital radiation therapy    

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GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Frontiers of Medicine doi: 10.1007/s11684-023-1007-9

Abstract: interacts with the core subunits of the glucose-induced degradation-deficient (GID) ubiquitin ligase complex, an evolutionarily conserved ubiquitin ligase complex and is ubiquitinated by itself.The protein levels of GID complex subunits increased reciprocally with TET2 level upon NSC differentiationThe silencing of the core subunits of the GID complex, including WDR26 and ARMC8, attenuated the ubiquitinationOur results illustrated that the GID complex negatively regulates TET2 protein stability, further modulates

Keywords： TET2     GID complex     neural stem cells     differentiation of neurons    

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Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 667-677 doi: 10.1007/s11684-017-0583-y

Abstract: recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated

Keywords： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: However, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associated

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract: Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active

Keywords： cancer-associated fibroblast     breast cancer     progression     prognosis    

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Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems

Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 284-292 doi: 10.1007/s11783-013-0555-7

Abstract: Polycyclic aromatic hydrocarbons (PAHs) are complex organic compounds which are identified as significantThe goal of this work was to investigate particle associated PAHs sampling artifacts caused by ozoneHigh temperature can increase loss of particle associated PAHs during sampling.

Keywords： particle associated polycyclic aromatic hydrocarbons (PAHs)     ozone     denuder     sampling artifacts    

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Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 158-163 doi: 10.1007/s11684-009-0042-5

Abstract: The regulatory effect of basic fibroblast growth factor (bFGF) mediated by recombinant adeno-associated

Keywords： tetracycline regulatory system     adeno-associated virus     basic fibroblast growth factor     gene regulation    

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Impacts of backwashing on micropollutant removal and associated microbial assembly processes in sand

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1634-z

Abstract:

● Backwashing in sand filters with 2-h and 4-h EBCTs was simulated.

Keywords： Sand filter     Backwashing     Recovery     Micropollutants     Community composition    

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Title Author Date Type Operation

Nascent Polypeptide-Associated Complex Involved in the Development and Pathogenesis of Fusarium graminearum

Xuli Wang, Xin Xie, Jin Liu, Guo-Liang Wang, Dewen Qiu

Journal Article

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Journal Article

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Journal Article

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Journal Article

Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling

Journal Article

Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Journal Article

Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery

Yutao Liu, Yaxia Di, Shuai Fu

Journal Article

The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid

Yang Wang, Huifang Zhou, Xianqun Fan

Journal Article

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Journal Article

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems

Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG

Journal Article

Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Journal Article

Impacts of backwashing on micropollutant removal and associated microbial assembly processes in sand

Journal Article